Why do you need a UTI Vaccine?

A urinary tract infection (UTI) is an infection in any part of your urinary system (kidneys, ureters, bladder, urethra). Most UTIs involve the bladder and the urethra. Women are at greater risk than men of developing a UTI. A UTI that is limited to your bladder can be painful but is typically not life threatening. Serious consequences can occur if a UTI spreads to your kidneys and a UTI can be life threatening if the infection spreads to your bloodstream.

When the infection spreads outside of the urinary system and to your blood or other organs, it can be life threatening; this is called urosepsis. The most common, and a particularly deadly form, is called Extraintestinal pathogenic Escherichia coli disease (ExPEC). ExPEC is a leading cause of adult bacteremia (sepsis). Some strains of ExPEC do not respond to drugs which cause an obstacle to treatment and may lead to hospitalization and death.

Although ExPEC disease can affect all ages, adults over the age of 60 years have an increased risk of developing this deadly disease. Those individuals who have had a urinary tract infection (UTI) in the last 2 years are most at risk. Prevention is the best way to fight this disease. An effective vaccine against ExPEC infection is urgently needed.

How do I know I have a UTI?

  • A strong, persistent urge to urinate
  • A burning sensation when urinating
  • Passing frequent, small amounts of urine
  • Urine that appears cloudy
  • Urine that appears red, bright pink or cola-colored — a sign of blood in the urine
  • Strong-smelling urine
  • Pelvic pain, in women — especially in the center of the pelvis and around the area of the pubic bone  

How do I know if it has spread to my bloodstream?

When it spreads to your bloodstream, it may cause ExPEC disease.

The symptoms include:

  • High fever
  • Shaking and chills
  • Nausea
  • Vomiting

For more information on an experimental vaccine to prevent life-threatening complications of a UTI, click on the contact form.


This study is enrolling soon!



  • History of Urinary Tract Infections
  • 60 years of age or older